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Ms. Michelle R Agyare-Tabbi
Degree(s): Bachlelor of Science
Job Title: MSc Student
Department: Molecular and Cellular Biology
Institution: University of Guelph
315 Gosling Gardens
Guelph, Ontario N1L0M1
Work Phone: 2262180570
Section Affiliation: Molecular Genetics and Cellular Microbiology
Error-prone polymerases facilitate translesion DNA synthesis and confer tolerance to DNA damage. Upregulation of these polymerases during stress-induced DNA damage results in increased rates of mutagenesis, ultimately leading to antimicrobial resistance. The deletion of genes encoding error-prone polymerases confers sensitivity to DNA damage in Candida albicans.
Keywords: Fungi, Error-prone polymerases, antifungal drug resistance, mutagenesis, experimental evolution